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Article

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

1 Nov 2008

Abstract excerpt

The stabilization and subcellular localization of the p19(Arf) tumor suppressor protein and the SUMO-2/3 deconjugating protease Senp3 each depend upon their binding to the abundant nucleolar protein nucleophosmin (Npm/B23). Senp3 and p19(Arf) antagonize each other's functions in regulating the SUMOylation of target proteins including Npm itself. The p19(Arf) protein triggers the sequential phosphorylation,...

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PMID: 18948745
DOI: 10.4161/cc.7.21.6930

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