Article
Glucocorticoid receptor gene polymorphisms and susceptibility to rheumatoid arthritis.
Clinical endocrinology - 1 Sept 2007
Donn Rachelle, Payne Debbie, Ray David
Abstract excerpt
BACKGROUND: A defect in hypothalamic-pituitary-adrenal (HPA) axis function has been suggested to contribute to susceptibility to rheumatoid arthritis (RA). OBJECTIVE: To investigate polymorphisms of the glucocorticoid receptor (GR) gene and determine any associations with RA. METHODS: Three GR polymorphisms that tag 95% of all haplotypes across the GR gene were genotyped. These are an intron B Bcl1 polymorphism,...
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