Article
HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.
Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017
Magnani Natalia D, Dada Laura A, Queisser Markus A, Brazee Patricia L, Welch Lynn C, Anekalla Kishore R, Zhou Guofei, Vagin Olga, Misharin Alexander V, Budinger G R Scott, Iwai Kazuhiro, Ciechanover Aaron J, Sznajder Jacob I
Abstract excerpt
Organisms have evolved adaptive mechanisms in response to stress for cellular survival. During acute hypoxic stress, cells down-regulate energy-consuming enzymes such as Na,K-ATPase. Within minutes of alveolar epithelial cell (AEC) exposure to hypoxia, protein kinase C zeta (PKCζ) phosphorylates the α1-Na,K-ATPase subunit and triggers it for endocytosis, independently of the hypoxia-inducible factor (HIF)....
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