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Article

Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis.

The Journal of biological chemistry - 10 May 2002

Doné Stefania Cotta, Leibiger Ingo B, Efendiev Riad, Katz Adrian I, Leibiger Barbara, Berggren Per-Olof, Pedemonte Carlos H, Bertorello Alejandro M

Abstract excerpt

In renal epithelial cells endocytosis of Na(+),K(+)-ATPase molecules is initiated by phosphorylation of its alpha(1)-subunit, leading to activation of phosphoinositide 3-kinase and adaptor protein-2 (AP-2)/clathrin recruitment. The present study was performed to establish the identity of the AP-2 recognition domain(s) within the Na(+),K(+)-ATPase alpha(1)-subunit. We identified a conserved sequence (Y(537)LEL)...

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Identifiers

PMID: 11859087
DOI: 10.1074/jbc.M201326200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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