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Article

Estrogen receptor-alpha genotype affects exercise-related reduction of arterial stiffness.

Medicine and science in sports and exercise - 1 Feb 2008

Hayashi Koichiro, Maeda Seiji, Iemitsu Motoyuki, Otsuki Takeshi, Sugawara Jun, Tanabe Takumi, Miyauchi Takashi, Kuno Shinya, Ajisaka Ryuichi, Matsuda Mitsuo

Abstract excerpt

PURPOSE: Arterial stiffness, an independent risk factor for cardiovascular disease, increases with advancing age. Arterial stiffness is improved by regular exercise, but individual responses to exercise training are variable. Given that estrogen and estrogen receptor-alpha (ER-alpha) can induce vasodilation and can exert an antiatherosclerotic effect in vessels, we hypothesized that gene polymorphisms of ER-alpha...

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Identifiers

PMID: 18202578
DOI: 10.1249/mss.0b013e31815c04cf

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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