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Article

Polymorphism in endothelin-related genes limits exercise-induced decreases in arterial stiffness in older subjects.

Hypertension (Dallas, Tex. : 1979) - 1 May 2006

Iemitsu Motoyuki, Maeda Seiji, Otsuki Takeshi, Sugawara Jun, Tanabe Takumi, Jesmin Subrina, Kuno Shinya, Ajisaka Ryuichi, Miyauchi Takashi, Matsuda Mitsuo

Abstract excerpt

Increase in arterial stiffness is associated with aging, which is improved by regular exercise. Endothelin (ET) system has crucial roles in regulating vascular tone and in the progression of atherosclerosis. We hypothesized that molecular variations (ie, gene polymorphisms) in ET-related gene might affect exercise-induced improvement in arterial stiffness with age in human subjects. The present study provides a...

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Identifiers

PMID: 16567585
DOI: 10.1161/01.HYP.0000217520.44176.73

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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