Assessing the influence of a genetic characteristic on disease in the presence of a strong environmental etiology.

Abstract excerpt

An inference as to the possible causal role of a genetic characteristic in the development of a disease is strengthened when there is a large disparity in disease incidence between persons with and without that characteristic. If the disparity is particularly great when, based on the presence or absence of a strong environmental risk factor, we would predict it to be so, then a causal inference is further...

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