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Article

Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2018

Mortensen Holly M, Chamberlin John, Joubert Bonnie, Angrish Michelle, Sipes Nisha, Lee Janice S, Euling Susan Y

Abstract excerpt

Estimation of susceptibility differences in human health risk assessment (HHRA) has been challenged by a lack of available susceptibility and variability data after exposure to a specific environmental chemical or pharmaceutical. With the increasingly large number of available data sources that contain polymorphism and other genetic data, human genetic variability that informs susceptibility can be better...

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Identifiers

PMID: 29476236
DOI: 10.1007/s00335-018-9738-7
PMCID: PMC9074075

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Source receipt: pubmed, retrieved 7 Sept 2026.

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