Article
An epidemiologic approach to gene-environment interaction.
Genetic epidemiology - 1 Jan 1990
Ottman R
Abstract excerpt
This paper illustrates how epidemiologic principles can be used to investigate relationships between genetic susceptibility and other risk factors for disease. Five plausible models are described for relationships between genetic and environmental effects, and an example of a simple mendelian disorder that fits each model is given. Each model leads to a different set of predictions about disease risk in...
Topics
- Case-Control Studies
- Cohort Studies
- Epidemiology
- Genetic Markers
- Genetic Predisposition to Disease
- Humans
- Models, Genetic
- Research Design
- Risk Factors