Article
Statistical analysis of molecular epidemiology studies employing case-series.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 1994
Begg C B, Zhang Z F
Abstract excerpt
The case-series design is being used increasingly to explore associations between environmental risk factors and genetic markers. It is demonstrated that the odds ratio derived from a case-series study is the ratio of the relative risk for developing marker-positive disease to the relative risk for developing marker-negative disease. This parameter is an empirical manifestation of etiological heterogeneity with...
Topics
- Biomarkers, Tumor
- Case-Control Studies
- Confidence Intervals
- Genetic Markers
- Humans
- Mathematical Computing
- Models, Genetic
- Mutation
- Occupational Exposure
- Odds Ratio