Article
A novel LRRK2 mutation in an Austrian cohort of patients with Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 15 Aug 2007
Haubenberger Dietrich, Bonelli Silvia, Hotzy Christoph, Leitner Petra, Lichtner Peter, Samal Doris, Katzenschlager Regina, Djamshidian Atbin, Brücke Thomas, Steffelbauer Michaela, Bancher Christian, Grossmann Josef, Ransmayr Gerhard, Strom Tim M, Meitinger Thomas, Gasser Thomas, Auff Eduard, Zimprich Alexander
Abstract excerpt
To investigate the frequency of mutations in the Leucine-Rich Repeat Kinase 2 gene (LRRK2) in a sample of Austrian Parkinson's disease (PD) patients, we sequenced the complete coding region in 16 patients with autosomal dominant PD. Furthermore, we sequenced exons 31, 35, and 41 additionally in 146 patients with idiopathic PD and 30 patients with dementia with Lewy bodies. Furthermore, all 192 patients were...
Topics
- Aged
- Asparagine
- Austria
- Cohort Studies
- DNA Mutational Analysis
- Exons
- Family Health
- Female
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2