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Article

Multigene amplification and massively parallel sequencing for cancer mutation discovery.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Dahl Fredrik, Stenberg Johan, Fredriksson Simon, Welch Katrina, Zhang Michael, Nilsson Mats, Bicknell David, Bodmer Walter F, Davis Ronald W, Ji Hanlee

Abstract excerpt

We have developed a procedure for massively parallel resequencing of multiple human genes by combining a highly multiplexed and target-specific amplification process with a high-throughput parallel sequencing technology. The amplification process is based on oligonucleotide constructs, called selectors, that guide the circularization of specific DNA target regions. Subsequently, the circularized target sequences...

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Identifiers

PMID: 17517648
DOI: 10.1073/pnas.0702165104
PMCID: PMC1871563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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