Article
Somatic complex I disruptive mitochondrial DNA mutations are modifiers of tumorigenesis that correlate with low genomic instability in pituitary adenomas.
Human molecular genetics - 15 Jan 2013
Kurelac Ivana, MacKay Alan, Lambros Maryou B K, Di Cesare Erica, Cenacchi Giovanna, Ceccarelli Claudio, Morra Isabella, Melcarne Antonio, Morandi Luca, Calabrese Francesco Maria, Attimonelli Marcella, Tallini Giovanni, Reis-Filho Jorge S, Gasparre Giuseppe
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations leading to the disruption of respiratory complex I (CI) have been shown to exhibit anti-tumorigenic effects, at variance with those impairing only the function but not the assembly of the complex, which appear to contribute positively to cancer development. Owing to the challenges in the analysis of the multi-copy mitochondrial genome, it is yet to be determined whether...
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