Article
Fiber hypertrophy and increased oxidative capacity can occur simultaneously in pig glycolytic skeletal muscle.
American journal of physiology. Cell physiology - 15 Feb 2014
Scheffler T L, Scheffler J M, Park S, Kasten S C, Wu Y, McMillan R P, Hulver M W, Frisard M I, Gerrard D E
Abstract excerpt
An inverse relationship between skeletal muscle fiber cross-sectional area (CSA) and oxidative capacity suggests that muscle fibers hypertrophy at the expense of oxidative capacity. Therefore, our objective was to utilize pigs possessing mutations associated with increased oxidative capacity [AMP-activated protein kinase (AMPKγ3(R200Q))] or fiber hypertrophy [ryanodine receptor 1 (RyR1(R615C))] to determine if...
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