Article
UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin.
Cancer research - 15 Nov 2001
Luo J L, Tong W M, Yoon J H, Hergenhahn M, Koomagi R, Yang Q, Galendo D, Pfeifer G P, Wang Z Q, Hollstein M
Abstract excerpt
The major etiological agent contributing to human nonmelanoma skin cancer is sunlight. The p53 tumor suppressor gene is usually mutated in these tumors, and the mutations are "UV signature" single or tandem transitions at dipyrimidine sequences in the DNA-binding domain (DBD). Cells that harbor these characteristic mutations are already present in sun-exposed skin areas of healthy individuals, and small epidermal...
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