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Article

Initiation of plasma-cell differentiation is independent of the transcription factor Blimp-1.

Immunity - 1 May 2007

Kallies Axel, Hasbold Jhagvaral, Fairfax Kirsten, Pridans Clare, Emslie Dianne, McKenzie Brent S, Lew Andrew M, Corcoran Lynn M, Hodgkin Philip D, Tarlinton David M, Nutt Stephen L

Abstract excerpt

Blimp-1 is considered an essential regulator of the terminal differentiation of B cells into antibody-secreting plasma cells. We show here that Rag1-/- mice reconstituted with fetal liver cells homozygous for a DNA-binding-deficient mutant of Prdm1 (the gene encoding Blimp-1) lack a defined plasm...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17509907
DOI: 10.1016/j.immuni.2007.04.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17509907-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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