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Article

A hierarchical model for estimating significance levels of non-parametric linkage statistics for large pedigrees.

Genetic epidemiology - 1 Jul 2007

Brock Guy N, Weeks Daniel E, Sobel Eric, Feingold Eleanor

Abstract excerpt

The significance level of a non-parametric linkage (NPL) statistic is often found by simulation since the distribution of the test statistic is complex and unknown. Ideally, simulation occurs by randomly assigning founder genotypes and then simulating meiotic events for the descendants in the pedigree, commonly referred to as 'gene dropping'. The missing data pattern in the original pedigree, including lack of...

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Identifiers

PMID: 17508354
DOI: 10.1002/gepi.20222

Genes

NPL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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