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Article

Ascertainment correction for Markov chain Monte Carlo segregation and linkage analysis of a quantitative trait.

Genetic epidemiology - 1 Sept 2007

Ma Jianzhong, Amos Christopher I, Warwick Daw E

Abstract excerpt

Although extended pedigrees are often sampled through probands with extreme levels of a quantitative trait, Markov chain Monte Carlo (MCMC) methods for segregation and linkage analysis have not been able to perform ascertainment corrections. Further, the extent to which ascertainment of pedigrees leads to biases in the estimation of segregation and linkage parameters has not been previously studied for MCMC...

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PMID: 17487893
DOI: 10.1002/gepi.20231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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