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Article

CSN5/Jab1 mutations affect axis formation in the Drosophila oocyte by activating a meiotic checkpoint.

Development (Cambridge, England) - 1 Nov 2002

Doronkin Sergey, Djagaeva Inna, Beckendorf Steven K

Abstract excerpt

The COP9 signalosome (CSN) is linked to signaling pathways and ubiquitin-dependent protein degradation in yeast, plant and mammalian cells, but its roles in Drosophila development are just beginning to be understood. We show that during oogenesis CSN5/JAB1, one subunit of the CSN, is required for meiotic progression and for establishment of both the AP and DV axes of the Drosophila oocyte. The EGFR ligand Gurken...

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Identifiers

PMID: 12397113
DOI: 10.1242/dev.129.21.5053

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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