Article
Regulation of Lck and Fyn tyrosine kinase activities by transmembrane protein tyrosine phosphatase leukocyte common antigen-related molecule.
Molecular cancer research : MCR - 1 Dec 2002
Tsujikawa Kazutake, Ichijo Tomoko, Moriyama Kazuki, Tadotsu Noriko, Sakamoto Kazuhiro, Sakane Naoki, Fukada So-ichiro, Furukawa Tatsuhiko, Saito Haruo, Yamamoto Hiroshi
Abstract excerpt
Leukocyte common antigen-related molecule (LAR) is a receptor-like protein tyrosine phosphatase (PTPase) with two PTPase domains. In the present study, we detected the expression of LAR in the brain, kidney, and thymus of mice using anti-LAR PTPase domain subunit monoclonal antibody (mAb) YU1. In the thymus, LAR was expressed on CD4(-)CD8(-) and CD4(-)CD8(low) thymocytes. The development of thymocytes in CD45...
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