Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood.

Calcified tissue international - 1 Jul 2007

Koay M Audrey, Tobias Jonathan H, Leary Sam D, Steer Colin D, Vilariño-Güell Carles, Brown Matthew A

Abstract excerpt

Bone mass acquired during childhood is the primary determinant of adult bone mineral density (BMD) and osteoporosis risk. Bone accrual is subject to genetic influences. Activating and inactivating LRP5 gene mutations elicit extreme bone phenotypes, while more common LRP5 polymorphisms are associated with normal variation of BMD. Our aim was to test the hypothesis that LRP5 gene polymorphisms influence bone mass...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Body Weight
Share to Bone Density

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Models, Genetic

Share to Models, Statistical

Source

Open in PubMed Open full text

Identifiers

PMID: 17505772
DOI: 10.1007/s00223-007-9024-2
PMCID: PMC2742716

Genes

LRP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood.PMID 17505772Read ↗

The impact of LRP5 polymorphism (rs556442) on calcium homeostasis, bone mineral density, and body composition in Iranian children.Semantic proximity Read ↗

Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with variation in vertebral bone mass, vertebral bone size, and stature in whites.Semantic proximity Read ↗

Genetics of Bone Mass in Childhood and Adolescence: Effects of Sex and Maturation Interactions.Semantic proximity Read ↗

The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men.Semantic proximity Read ↗

Influence of LRP5 polymorphisms on normal variation in BMD.Semantic proximity Read ↗

Genetic variants in adult bone mineral density and fracture risk genes are associated with the rate of bone mineral density acquisition in adolescence.Semantic proximity Read ↗

Genetically Determined Later Puberty Impacts Lowered Bone Mineral Density in Childhood and Adulthood.Semantic proximity Read ↗

LRP5 gene polymorphism and cortical bone.Semantic proximity Read ↗

Association between LRP5 polymorphism and bone mineral density: a Bayesian meta-analysis.Semantic proximity Read ↗

LRP5-related primary osteoporosis: phenotypic spectrum and treatment response to zoledronic acid.Semantic proximity Read ↗

Low-density lipoprotein receptor-related protein 5 (LRP5) gene polymorphisms are associated with bone mass in both Chinese and whites.Semantic proximity Read ↗

Polymorphisms in the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with peak bone mass in non-sedentary men: results from the Odense androgen study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.