Article
The Clr4 methyltransferase determines the subnuclear localization of the mating-type region in fission yeast.
Journal of cell science - 1 Jun 2007
Alfredsson-Timmins Jenny, Henningson Frida, Bjerling Pernilla
Abstract excerpt
The genome has a non-random spatial distribution in the cell nucleus. In Schizosaccharomyces pombe, it has been shown that the centromeres, telomeres and the mating-type region localize to the nuclear membrane (NM), the former by attaching to the spindle pole body (SPB). In addition, reporter genes inserted into these areas are transcriptionally repressed because of the formation of specialized chromatin...
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