Article
An N-terminal nucleotide-binding site in VDAC1: involvement in regulating mitochondrial function.
Journal of cellular physiology - 1 Aug 2007
Yehezkel Galit, Abu-Hamad Salah, Shoshan-Barmatz Varda
Abstract excerpt
In a previous study, we presented evidence for the existence of a nucleotide-binding site (NBS) in the N-terminal region of the voltage-dependent anion channel (VDAC1). In this study, further localization and possible roles of the proposed VDAC1-NBS were investigated using site-directed mutagenesis. The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a...
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