An N-terminal nucleotide-binding site in VDAC1: involvement in regulating mitochondrial function.

doi:10.1002/jcp.21048

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Article

An N-terminal nucleotide-binding site in VDAC1: involvement in regulating mitochondrial function.

Journal of cellular physiology - 1 Aug 2007

Yehezkel Galit, Abu-Hamad Salah, Shoshan-Barmatz Varda

Abstract excerpt

In a previous study, we presented evidence for the existence of a nucleotide-binding site (NBS) in the N-terminal region of the voltage-dependent anion channel (VDAC1). In this study, further localization and possible roles of the proposed VDAC1-NBS were investigated using site-directed mutagenesis. The predicated NBS of murine VDAC1 (mVDAC1) was mutated by replacing two glycine residues with alanines or a...

Topics

Adenosine Triphosphate
Alanine
Apoptosis
Binding Sites
Cell Line
Cell Proliferation
Cytosol
Glycine
Humans
Lysine
Mitochondria
Mitochondrial Membranes
Mutation
Permeability
Protein Structure, Tertiary
RNA Interference
RNA, Small Interfering
Saccharomyces cerevisiae

Source

Open in PubMed

Identifiers

PMID: 17503466
DOI: 10.1002/jcp.21048

Genes

VDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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