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Article

Selectivity changes in site-directed mutants of the VDAC ion channel: structural implications.

Science (New York, N.Y.) - 9 Mar 1990

Blachly-Dyson E, Peng S, Colombini M, Forte M

Abstract excerpt

The gene encoding the yeast mitochondrial outer membrane channel VDAC was subjected to site-directed mutagenesis to change amino acids at 29 positions to residues differing in charge from the wild-type sequence. The mutant genes were then expressed in yeast, and the physiological consequences of single and multiple amino acid changes were assessed after isolation and insertion of mutant channels into phospholipid...

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Source

Identifiers

PMID: 1690454
DOI: 10.1126/science.1690454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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