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Article

Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.

Journal of the American College of Cardiology - 15 May 2007

Mathew Joseph P, Podgoreanu Mihai V, Grocott Hilary P, White William D, Morris Richard W, Stafford-Smith Mark, Mackensen G Burkhard, Rinder Christine S, Blumenthal James A, Schwinn Debra A, Newman Mark F

Abstract excerpt

OBJECTIVES: We hypothesized that candidate gene polymorphisms in biologic pathways regulating inflammation, cell matrix adhesion/interaction, coagulation-thrombosis, lipid metabolism, and vascular reactivity are associated with postoperative cognitive deficit (POCD). BACKGROUND: Cognitive decline is a common complication of coronary artery bypass graft (CABG) surgery and is associated with a reduced quality of...

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PMID: 17498578
DOI: 10.1016/j.jacc.2007.01.080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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