Article
Evidence for association of endothelial cell nitric oxide synthase gene polymorphism with earlier progression to end-stage renal disease in a cohort of Hellens from Greece and Cyprus.
Genetic testing - 1 Jan 2004
Lamnissou Klea, Zirogiannis Panos, Trygonis Sotiris, Demetriou Kyproula, Pierides Alkis, Koptides Michael, Deltas C Constantinou
Abstract excerpt
Nitric oxide (NO) is thought to be an important factor in the deterioration of renal function. A variable-number tandem 27-bp repeat in intron 4 of the endothelial cell nitric oxide synthase (NOS3) gene has been found to be associated with the plasma levels of NO metabolites. Two alleles are of varied frequencies in different populations (a and b). The shorter allele a has been associated in Japanese populations...
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