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Article

Engineering cis-telomerase RNAs that add telomeric repeats to themselves.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 2010

Qiao Feng, Goodrich Karen J, Cech Thomas R

Abstract excerpt

Telomerase is a ribonucleoprotein complex consisting of a protein reverse transcriptase (TERT) and an RNA subunit (TR). Telomerase normally adds telomeric DNA repeats to chromosome ends. Here, we engineer human and Tetrahymena cis-telomerase RNAs, each having a DNA primer covalently linked to its 3' end. We find that cis-telomerase synthesizes DNA with increased repeat addition processivity (RAP) but does not...

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Share to TERT gene
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Repetitive Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 20194781
DOI: 10.1073/pnas.0909366107
PMCID: PMC2841905

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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