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Article

Defective retrotranslocation causes loss of anti-Bax function in human familial prion protein mutants.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 May 2007

Jodoin Julie, Laroche-Pierre Stéphanie, Goodyer Cynthia G, LeBlanc Andréa C

Abstract excerpt

Prion protein (PrP) inhibits the activation of proapoptotic Bax in primary human neurons and MCF-7 cells. Because neuronal apoptosis occurs in human prion diseases, here we examine the anti-Bax function of familial PrP mutants. All Creutzfeldt-Jakob disease and fatal familial insomnia-associated prion protein mutations partially or completely lose the anti-Bax function in human neurons and, except for A117V and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17494694
DOI: 10.1523/JNEUROSCI.0957-07.2007
PMCID: PMC6672383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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