Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.

Bioscience reports - 30 Sept 2020

Akintade Damilare D, Chaudhuri Bhabatosh

Abstract excerpt

Apoptosis is a form of programmed cell death which is essential for the growth of dividing human cells whereas, in contrast, it is deleterious for post-mitotic cells such as neurons. Bax and α-synuclein are two human proteins which play a role in the induction of neuronal apoptosis in neurodegenerative diseases like Alzheimer's and Parkinson's. Human Bax and α-synuclein also induce cell death when expressed in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to bcl-2-Associated X Protein
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Galactokinase

Share to Gene Dosage

Share to Membrane Potential, Mitochondrial

Share to Parkinson Disease

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 32794578
DOI: 10.1042/BSR20201912
PMCID: PMC7468099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

The effect of copy number on α-synuclein's toxicity and its protective role in Bax-induced apoptosis, in yeast.PMID 32794578Read ↗

Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein.Semantic proximity Read ↗

Antiapoptotic property of human alpha-synuclein in neuronal cell lines is associated with the inhibition of caspase-3 but not caspase-9 activity.Semantic proximity Read ↗

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli.Semantic proximity Read ↗

Direct α-synuclein promoter transactivation by the tumor suppressor p53Semantic proximity Read ↗

Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease.Semantic proximity Read ↗

Mammalian prion protein suppresses Bax-induced cell death in yeast.Semantic proximity Read ↗

[The effect of small ubiquitin-like modifier-1 modification on the formation of Lewy body-like inclusions in cytoplasm and apoptosis of HEK293 cell induced by overexpression and mutation of alpha-synuclein].Semantic proximity Read ↗

Defective retrotranslocation causes loss of anti-Bax function in human familial prion protein mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.