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Article

Involvement of the N-terminus of Bax in its intracellular localization and function.

FEBS letters - 13 Feb 2002

Cartron P-F, Moreau C, Oliver L, Mayat E, Meflah K, Vallette F M

Abstract excerpt

We have identified, using site-directed mutagenesis, a proline located at position 13 of Baxalpha (Bax) as crucial for the maintenance of its cytosolic conformation. The substitution of this proline by a valine results in a strong binding of Bax to mitochondria and to conformational changes monitored by a decreased sensitivity of Bax to mild proteolysis and the enhancement of its oligomerization state. Deletion...

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Identifiers

PMID: 11852059
DOI: 10.1016/s0014-5793(02)02227-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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