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Article

Association of Bcl-2 with misfolded prion protein is linked to the toxic potential of cytosolic PrP.

Molecular biology of the cell - 1 Aug 2006

Rambold Angelika S, Miesbauer Margit, Rapaport Doron, Bartke Till, Baier Michael, Winklhofer Konstanze F, Tatzelt Jörg

Abstract excerpt

Protein misfolding is linked to different neurodegenerative disorders like Alzheimer's disease, polyglutamine, and prion diseases. We investigated the cytotoxic effects of aberrant conformers of the prion protein (PrP) and show that toxicity is specifically linked to misfolding of PrP in the cytosolic compartment and involves binding of PrP to the anti-apoptotic protein Bcl-2. PrP targeted to different cellular...

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Identifiers

PMID: 16707568
DOI: 10.1091/mbc.e06-01-0083
PMCID: PMC1525242

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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