Human leukocyte antigen genotype modulates cytomegalovirus- and Epstein-Barr virus-specific T-cell response in healthy donors for optimized virus-specific T-cell donor selection.

doi:10.3389/fimmu.2026.1856550

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Article

Human leukocyte antigen genotype modulates cytomegalovirus- and Epstein-Barr virus-specific T-cell response in healthy donors for optimized virus-specific T-cell donor selection.

Frontiers in immunology - 1 Jan 2026

Mora-Buch Rut, Pasamar Helena, Tomás-Marín Maria, Enrich Emma, Andrés-Rozas María, Peña-Gómez Cleofé, García Bosca Miriam, Rudilla Francesc

Abstract excerpt

Introduction: Reactivation of cytomegalovirus (CMV) and Epstein-Barr virus (EBV) is a major complication in immunocompromised patients, and understanding donor variability in antiviral immunity is essential for optimizing adoptive T-cell therapy. This study aimed to identify immunogenetic determinants of virus-specific T-cell responses in healthy donors to guide donor selection. Methods: CMV- and EBV-specific...

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Topics

Humans
Herpesvirus 4, Human
Cytomegalovirus
HLA Antigens
Genotype
Epstein-Barr Virus Infections

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cytomegalovirus Infections

CD8-Positive T-Lymphocytes

Donor Selection

Phosphoproteins

T-Lymphocytes

Viral Matrix Proteins

CD4-Positive T-Lymphocytes

Lymphocyte Activation

Source

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Identifiers

PMID: 42694534
DOI: 10.3389/fimmu.2026.1856550
PMCID: PMC13539606

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