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Article

Dominant epitopes presented by prevalent HLA alleles permit wide use of banked CMVpp65 T cells in adoptive therapy.

Blood advances - 23 Aug 2022

Hasan Aisha N, Doubrovina Ekaterina, Sottile Rosa, Prockop Susan, Klatt Martin G, Heller Glenn, Selvakumar Annamalai, Barnett Lorna, Hsu Katharine C, O'Reilly Richard J

Abstract excerpt

We established and characterized a bank of 138 CMVpp65 peptide-specific T-cell (CMVpp65CTLs) lines from healthy marrow transplant donors who consented to their use for treatment of individuals other than their transplant recipient. CMVpp65CTL lines included 131 containing predominantly CD8+ T cells and 7 CD4+ T cells. CD8+ CMVpp65CTLs were specific for 1 to 3 epitopes each presented by one of only 34 of the 148...

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Identifiers

PMID: 35605246
DOI: 10.1182/bloodadvances.2022007005
PMCID: PMC9631666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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