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Article

Genomic and functional evidence for an <i>ARID1A</i> tumor suppressor role

10 May 2007

Abstract excerpt

ARID1A is located in 1p36.11, a region frequently deleted in human cancers. Using a novel method to screen for tumorigenic cDNA sequences, we have identified ARID1A as a presumptive tumor suppressor gene. The transforming ARID1A sequence was an antisense cDNA, and was the product of a genomic rearrangement, as corroborated in the primary breast carcinoma from which the cDNA had been obtained. In further...

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PMID: 17492758
DOI: 10.1002/gcc.20459

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