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Article

Evidence for the presence of somatic mitochondrial DNA mutations in right atrial appendage tissues of coronary artery disease patients.

Molecular genetics and genomics : MGG - 1 Aug 2014

Matam Kavitha, Shaik Noor Ahmad, Aggarwal Sunil, Diwale Sameer, Banaganapalli Babajan, Al-Aama Jumana Yousuf, Elango Ramu, Rao Pragna, Hasan Qurratulain

Abstract excerpt

Coronary artery disease (CAD) is a multifactorial disease with the underlying involvement of environment, life style and nuclear genetics. However, the role of extranuclear genetic material in terms of somatically acquired mutations in mitochondrial tRNA and protein coding genes in the initiation or progression of CAD is not well defined. Hence, in the present study, right atrial appendage tissues and matched...

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PMID: 24604425
DOI: 10.1007/s00438-014-0828-2

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CAD

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