Article
Mitochondrial mutations in patients with congenital heart defects by next generation sequencing technology.
Cardiology in the young - 1 Apr 2015
Abaci Neslihan, Arıkan Muzaffer, Tansel Türkan, Sahin Nazlı, Cakiris Aris, Pacal Ferda, Sırma Ekmekci Sema, Gök Emre, Üstek Duran
Abstract excerpt
It has been shown that mitochondrial deoxyribo nucleic acid mutations may play an important role in the development of cardiomyopathy, and various types of cardiomyopathy can be attributed to disturbed mitochondrial oxidative energy metabolism. Several studies have described many mutations in mitochondrial genes encoding for subunits of respiratory chain complexes. Thus, recent studies confirm that pathologic...
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