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Article

Detection and validation of non-synonymous coding SNPs from orthogonal analysis of shotgun proteomics data.

Journal of proteome research - 1 Jun 2007

Bunger Maureen K, Cargile Benjamin J, Sevinsky Joel R, Deyanova Ekaterina, Yates Nathan A, Hendrickson Ronald C, Stephenson James L

Abstract excerpt

Orthogonal analysis of amino acid substitutions as a result of SNPs in existing proteomic datasets provides a critical foundation for the emerging field of population-based proteomics. Large-scale proteomics datasets, derived from shotgun tandem MS analysis of complex cellular protein mixtures, contain many unassigned spectra that may correspond to alternate alleles coded by SNPs. The purpose of this work was to...

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PMID: 17488105
DOI: 10.1021/pr0700908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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