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Article

De novo identification and quantification of single amino-acid variants in human brain.

Journal of molecular cell biology - 1 Oct 2014

Su Zhi-Duan, Sheng Quan-Hu, Li Qing-Run, Chi Hao, Jiang Xi, Yan Zheng, Fu Ning, He Si-Min, Khaitovich Philipp, Wu Jia-Rui, Zeng Rong

Abstract excerpt

The detection of single amino-acid variants (SAVs) usually depends on single-nucleotide polymorphisms (SNPs) database. Here, we describe a novel method that discovers SAVs at proteome level independent of SNPs data. Using mass spectrometry-based de novo sequencing algorithm, peptide-candidates are identified and compared with theoretical protein database to generate SAVs under pairing strategy, which is followed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25007923
DOI: 10.1093/jmcb/mju031

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