Article
HSPVdb--the Human Short Peptide Variation Database for improved mass spectrometry-based detection of polymorphic HLA-ligands.
Immunogenetics - 1 Mar 2011
Nijveen Harm, Kester Michel G D, Hassan Chopie, Viars Aurélie, de Ru Arnoud H, de Jager Machiel, Falkenburg J H Fred, Leunissen Jack A M, van Veelen Peter A
Abstract excerpt
T cell epitopes derived from polymorphic proteins or from proteins encoded by alternative reading frames (ARFs) play an important role in (tumor) immunology. Identification of these peptides is successfully performed with mass spectrometry. In a mass spectrometry-based approach, the recorded tandem mass spectra are matched against hypothetical spectra generated from known protein sequence databases. Commonly used...
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