Article
Cholestasis is a marker for hepatocellular carcinomas displaying beta-catenin mutations.
The Journal of pathology - 1 Jul 2007
Audard V, Grimber G, Elie C, Radenen B, Audebourg A, Letourneur F, Soubrane O, Vacher-Lavenu M-C, Perret C, Cavard C, Terris B
Abstract excerpt
The Wnt/beta-catenin signalling pathway is activated in many human hepatocellular carcinomas (HCC). Identification of beta-catenin mutation relies mostly on sequence analysis and/or immunohistochemistry. beta-catenin mutation may also be detected by analysing the expression of its target genes. T...
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