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Article

The Patched gene is epigenetically regulated in ovarian dermoids and fibromas, but not in basocellular carcinomas

1 Jun 2007

Abstract excerpt

The Hedgehog/Patched signaling pathway plays a prominent role during mammalian development but it is also involved in oncogenic transformation. We investigated the methylation status of the Patched promotor in a set of basocellular carcinomas of the skin and ovarian tumors as an alternative to mutational causes of the pathway deregulation. Our aim was to define a possible role of genetic and/or epigenetic...

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Identifiers

PMID: 17487419
DOI: 10.3892/ijmm.19.6.875

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