Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses

Abstract excerpt

To understand the molecular biology of the nevoid basal cell carcinoma syndrome, the hedgehog signaling network is explained. The syndrome is caused by mutations in patched, a tumor suppressor gene. A single point mutation in one patched allele may be responsible for the malformations found in the syndrome. Inactivation of both patched alleles results in the formation of tumors and cysts (basal cell carcinomas, od...

Topics

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• Cancer and Skin Lesions
• Hedgehog Signaling Pathway Studies
• Oral and Maxillofacial Pathology

Identifiers and source

Literature Corpus work

39d274ce-885f-5ad9-ac8c-c5f337118467

DOI

10.1034/j.1399-0020.1999.283280314.x