Article
Glutathione S-transferase M1 polymorphism and sporadic colorectal cancer risk: An updating meta-analysis and HuGE review of 36 case-control studies.
Annals of epidemiology - 1 Feb 2010
Gao Yong, Cao Yunfei, Tan Aihua, Liao Cun, Mo Zengnan, Gao Feng
Abstract excerpt
PURPOSE: Sporadic colorectal cancer (CRC) is considered to be a multifactorial disease, in which multiple exposures to endogenous factors interact with individual genetic background in a complex manner, resulting in modulation of the risk. The glutathione S-transferase M1 gene (GSTM1) is a particularly attractive candidate for CRC susceptibility because it codes an enzyme involved in the metabolism of...
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