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Influence of Tumor Cell and Stroma Sensitivity on Tumor Response to Radiation

1 May 2007

Abstract excerpt

In this study, we evaluated the role of tumor cell and tumor stroma sensitivity as determinants of radiation-induced tumor growth delay. A DNA double-strand break repair-defective DNA-PKcs(-/-) tumor cell line and its radioresistant DNA-PKcs(+/+)-transfected counterpart were used to initiate tumors in nude and hypersensitive severe combined immunodeficient (SCID) mice. Insertion of the human DNA-PKcs(+/+) gene...

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PMID: 17483312
DOI: 10.1158/0008-5472.can-06-4498

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