Targeting tumor cells by enhancing radiation sensitivity.

Abstract excerpt

The work of Al Knudson created the paradigm in which we see cancer as a result of the accumulation of multiple mutations. Our goal has been to exploit these mutations to develop strategies to enhance therapy for cancer by targeting the malignant cell while sparing the normal tissue. In studying the RAS oncogene, we observed that its expression when activated resulted in enhanced radioresistance. Conversely,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to EGFR gene
• Share to PTEN gene
• Share to Mutation