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Article

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

Cancer research - 15 Oct 2010

García-Barros Mónica, Thin Tin Htwe, Maj Jerzy, Cordon-Cardo Carlos, Haimovitz-Friedman Adriana, Fuks Zvi, Kolesnick Richard

Abstract excerpt

Severe combined immunodeficient (SCID) mice carry a germ-line mutation in DNA-PK, associated with deficiency in recognition and repair DNA double-strand breaks. Thus, SCID cells and tissues display increased sensitivity to radiation-induced postmitotic (clonogenic) cell death. Nonetheless, the single-radiation doses required for 50% permanent local control (TCD(50)) of tumors implanted in SCID mice are not...

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Source

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Identifiers

PMID: 20924105
DOI: 10.1158/0008-5472.CAN-10-1871
PMCID: PMC2976483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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