Article
Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.
Radiation medicine - 1 Nov 2007
Sakata Koh-Ichi, Someya Masanori, Matsumoto Yoshihisa, Hareyama Masato
Abstract excerpt
Traditional radiobiology has aimed at elucidating the mechanism of radiosensitivity of cancer cells and normal cells. Because the mechanism of DNA double-strand break (DSB) repair, which is inherently important to radiosensitivity, was unknown, it has been difficult to obtain results applicable to clinical radiotherapy from traditional radiobiology research. Today, however, the molecular mechanism of DNA DSB...
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