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Article

Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.

International journal of hematology - 1 May 2007

Tanaka Miyuki, Gombart Adrian F, Koeffler H Phillip, Shiohara Masaaki

Abstract excerpt

Bactericidal/permeability-increasing protein (BPI) is a 55-kd cationic protein found mainly in neutrophil primary granules. BPI shows cytotoxicity against Gram-negative bacteria. In this study, we studied the role of a myeloid-specific transcription factor, CCAAT/enhancer binding protein epsilon...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 17483073
DOI: 10.1532/IJH97.05162

Genes

BPI
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17483073-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon.PMID 17483073Read ↗

Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon.Semantic proximity Read ↗

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Genotype-phenotype correlations in specific granule deficiency: loss of DNA-binding ability and impaired nuclear localization cause severe manifestations due to the c.655_665del CEBPE variant.Semantic proximity Read ↗

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CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicingSemantic proximity Read ↗

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