Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70.

doi:10.1074/jbc.M308848200

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Article

Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70.

The Journal of biological chemistry - 5 Mar 2004

Tsukahara Fujiko, Maru Yoshiro

Abstract excerpt

Heat shock cognate protein 70 (Hsc70) serves nuclear transport of several proteins as a molecular chaperone. We have recently identified a novel variant of human Hsc70, heat shock cognate protein 54 (Hsc54), that lacks amino acid residues 464-616 in the protein binding and variable domains of Hsc70. In the present study, we examined nucleocytoplasmic localization of Hsc70 and Hsc54 by using green fluorescent...

Topics

Active Transport, Cell Nucleus
Cell Nucleus
Green Fluorescent Proteins
HSC70 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
Humans
Luminescent Proteins
Mutation
Nuclear Localization Signals
Protein Structure, Tertiary
Recombinant Fusion Proteins

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PMID: 14684748
DOI: 10.1074/jbc.M308848200

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