Characterisation of nuclear localisation signals of the four human core histones.

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Article

Characterisation of nuclear localisation signals of the four human core histones.

Journal of cellular biochemistry - 26 Mar 2001

Baake M, Doenecke D, Albig W

Abstract excerpt

The four core histones H2A, H2B, H3 and H4 are transported from the cytoplasm into the nucleus by a receptor-mediated and energy-dependent process. This nuclear transport depends on topogenic signals in the individual histone protein sequences. We have analysed such nuclear localisation signals in the core histones by means of fusion proteins consisting of individual core histones (or fragments thereof) and...

Topics

Cell Nucleus
Cytoplasm
Fluorescent Antibody Technique, Indirect
HeLa Cells
Histones
Humans
Mutation
Nuclear Localization Signals
Plasmids
Protein Conformation
Protein Structure, Tertiary
Recombinant Fusion Proteins
Transfection
beta-Galactosidase

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Open in PubMed

Identifiers

PMID: 11241673

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